Bioprocess modeling, in silico
Deep process insights through modeling — for everyone.
You don't have to be a modeler, or a buffer chemist. We encode decades of bioprocess know-how into predictive, first-principles software — so you can characterize and verify a unit operation in silico, before you commit a single reagent. We start with buffers.
Starting with buffers
Buffers look simple. They aren't.
A buffer is "just" a recipe and a pH — until you account for multiple dissociation constants, ionic strength, and how a 10% weighing error moves the result. The Henderson–Hasselbalch equation ignores most of it. We model the real chemistry from first principles, so the prediction matches the meter — and so you can ask what if in software instead of at the bench.
One tool, three jobs
Design · Understand · Document
Design
Get the recipe right the first time.
The first-principles engine handles the hard chemistry — multiple pKas, ionic strength — so you don't have to be a buffer expert. Describe what you want, even in plain language, and get a recipe that hits target.
Understand
Run the experiments in silico.
Sweep concentrations, stress-test robustness with a ±10% heat-map, watch how salt shifts pH. Characterize a buffer and build real intuition — without using a single reagent.
Document
Walk into tech transfer with the report done.
Every buffer comes fully characterized — compounds, ions, ionic species, achievable-pH range, and sensitivity. A documentation package for the plant, generated, not measured.
Predict, don't pipette
The experiments you run in silico
Because the engine is predictive, each of these is an experiment you'd otherwise run slowly at the bench.
Predict & invert
Predict the pH of any composition — or design to a target pH.
Robustness heat-map
Perturb each component ±10% to find the robust operating point, not just a working one.
Ionic-strength effects
See how added salt shifts pKa and pH — exactly what Henderson–Hasselbalch misses.
Formulation bake-off
Same target, different species — compare achievability and robustness side by side.
Full characterization
Break any buffer down to compounds, ions, and ionic species with a charge balance.
Design-space scan
Find the feasible, robust region before you commit anything to the bench.
From bench to plant
The report, generated — not measured
The same model that designs a buffer documents it: composition, ion balance, achievable-pH range, and sensitivity. Assemble a comprehensive characterization for every buffer in your process — the package a tech transfer needs — without generating every data point at the bench.
The suite
Start with buffers. Build out the train.
Expert Buffer Designer is live today. The family extends from designing a buffer to making it at scale and keeping it in spec.
Expert Buffer Designer
Model pH and ionic strength from first principles, build single- or dual-species recipes, and see exactly how robust a buffer is — in your browser, or on iOS and Android.
Expert Buffer Stock Blending Designer
Plan and sequence buffer-stock blending and inline dilution — turn the recipes you design into a buffer-prep plan you can run at scale.
Expert Solution Adjustment Designer
Model pH and conductivity adjustments so you know exactly what to add, and how much, to land a solution on target without guess-and-check titration.
Try it on your next buffer
Free to use on the web, iOS, and Android.