Blog
Modeling deep-dives, product news, and practical guides for bioprocessing.
The Expert Bioprocess Designer Suite opens to invited testers with three apps: buffer design, solution operations and bioreactor design. Here's what they do, and how far to trust them.
Read more →108 buffer designs in 7.8 seconds. A 24-case viral-inactivation study in 12.5. We timed the assistant in Expert Buffer Designer and Expert Solution Operations Designer on four real questions, and checked every number.
Read more →The four buffer families side by side at 50 mM: where each one buffers, how hard, and how far its pH moves with temperature and salt.
Read more →Acetic acid plus sodium acetate, or acetic acid plus sodium hydroxide: the buffer comes out identical. Pick your pairs well and six chemicals make every acetate, citrate, phosphate and Tris buffer.
Read more →The same Protein A pool, one change at a time: hydrochloric acid needs a sixteenth of the volume of acetic acid, and a pool at pH 4.5 needs nearly three times the acid of one at pH 4.0.
Read more →A worked example: take a Protein A pool to pH 3.5 with acetic acid, then back to pH 7.8 with Tris, and find out how much acid and base it really takes, per liter of pool.
Read more →Designing a buffer is step one. Making it at manufacturing scale — blending, sequencing, inline dilution — is the next problem worth modeling.
Read more →Hitting your target pH isn't the goal — robustness is. A ±10% sensitivity check changes which formulation you pick.
Read more →Buffering species, compounds, concentrations. Every buffer follows the same three-step recipe.
Read more →Nearly every unit operation in biologics manufacturing runs on a buffer — which is exactly why getting them right, and robust, matters more than the simple recipe makes it look.
Read more →Henderson–Hasselbalch ignores ionic strength and multiple pKas. That's why your hand calc and your pH meter disagree.
Read more →Why we're building a modern suite of bioprocess modeling applications — and what you'll find here.
Read more →A short case for modeling buffer formulations in software instead of iterating at the bench.
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